Innoprot offers SH-SY5Y stably expressing tau-tGFP & alpha-synuclein-TagRFP as valuable tools to use as “in vitro” models for research studies.

Alpha-synuclein (also α-synuclein) is a protein whose function in the healthy brain is currently unknown. It is abundant in the brain but also appear smaller amounts in the heart, muscles, and other tissues. In the brain, alpha-synuclein appears mainly at the tips of nerve cells (neurons) in specialized structures called presynaptic terminals.

Tau represents the subunit protein of one of the major hallmarks of Alzheimer disease (AD), the neurofibrillary tangles; and is therefore of major interest as an indicator of disease mechanisms. They are abundant in neurons of the central nervous system and are less common elsewhere; but also appears at very low levels in CNS astrocytes and oligodendrocytes. They accumulate in neurofibrillary tangles in Alzheimer’s disease (AD) brain. There is significant evidence that a disruption of normal phosphorylation events results in tau dysfunction. It is a contributing factor to the pathogenic processes of neurodegenerative diseases, such as AD.