Fibroblasts are mesenchymal cells which came from the embryonic mesoderm. In general, fibroblasts secrete a non-rigid extracellular matrix which is rich in type I and/or type III collagen. There is evidence showing that fibroblasts in various organs are intrinsically different. They are important tools for a wide range of cellular and molecular studies, as they are one of the easiest types of cells to grow in culture. Their durability also makes them amenable to a variety of manipulations ranging from studies employing gene transfection to microinjection. Human Ocular Choroid Fibroblasts respond to elevated PKC and also cyclic AMP levels to up-regulate VEGF expression. It suggests a role in angiogenesis and macular degeneration.