SARS-CoV Spike Glycoprotein Cell Line from Innoprot stable expresses SARS-CoV Spike Glycoprotein. Coronaviruses (CoVs) infect human and animals and cause varieties of diseases, such as respiratory, enteric, renal, and neurological diseases. An outbreak of atypical pneumonia, termed severe acute respiratory syndrome (SARS), appeared in China in November, 2002. The mortality rates of the disease reached as high as 15% in some age groups.
SARS-CoV uses its spike glycoprotein (S), a main target for neutralization antibody, to bind its receptor, and mediate membrane fusion and virus entry. It uses hACE2 to enter cells, correlating with the efficient spread of SARS-CoV among humans. S comprises two functional subunits responsible for binding to the host cell receptor (S1 subunit) and also fusion of the viral and cellular membranes (S2 subunit). SARS-CoV Spike Glycoprotein Cell Line cell line allows the study of SARS-CoV spike/ACE2 interaction in cell-based assays.
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